Invention Grant
- Patent Title: Secretory immunoglobulin a (sIgA)-binding nucleic acid molecule, sIgA analysis sensor, and sIgA analysis method
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Application No.: US16333293Application Date: 2017-04-20
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Publication No.: US11236342B2Publication Date: 2022-02-01
- Inventor: Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Iwao Waga , Masayasu Kuwahara
- Applicant: NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
- Applicant Address: JP Tokyo; JP Gunma
- Assignee: NEC Solution Innovators, Ltd.,NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
- Current Assignee: NEC Solution Innovators, Ltd.,NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
- Current Assignee Address: JP Tokyo; JP Gunma
- Agency: Sughrue Mion, PLLC
- Priority: JPJP2016-180892 20160915
- International Application: PCT/JP2017/015934 WO 20170420
- International Announcement: WO2018/051569 WO 20180322
- Main IPC: C12N15/115
- IPC: C12N15/115 ; C12Q1/68 ; G01N33/53 ; C12N15/09
Abstract:
The present invention provides a novel molecule that can be used for detection of sIgA. The sIgA-binding nucleic acid molecule of the present invention is characterized in that it binds to secretory immunoglobulin A (sIgA) with a dissociation constant of 37.7 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 12 or a partial sequence thereof, for example. According to the sIgA-binding nucleic acid molecule of the present invention, it is possible to detect sIgA in saliva.
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