- Patent Title: Methods of modulating nucleic acid stability and protein expression
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Application No.: US15557412Application Date: 2016-03-09
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Publication No.: US11236345B2Publication Date: 2022-02-01
- Inventor: Jeffery M. Coller , Kristian E. Baker
- Applicant: CASE WESTERN RESERVE UNIVERSITY
- Applicant Address: US OH Cleveland
- Assignee: CASE WESTERN RESERVE UNIVERSITY
- Current Assignee: CASE WESTERN RESERVE UNIVERSITY
- Current Assignee Address: US OH Cleveland
- Agency: Tarolli, Sundheim, Covell & Tummino LLP
- International Application: PCT/US2016/021594 WO 20160309
- International Announcement: WO2016/145101 WO 20160915
- Main IPC: C12N15/68
- IPC: C12N15/68 ; C12N15/81 ; C12N15/67 ; C12P21/02 ; C12N15/85
Abstract:
A synthetic nucleic acid which encodes a protein wherein at least one optimal or non-optimal codon in a wild type nucleic acid encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.
Public/Granted literature
- US20180112226A1 METHODS OF MODULATING NUCLEIC ACID STABILITY AND PROTEIN EXPRESSION Public/Granted day:2018-04-26
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