Invention Grant
- Patent Title: Method for screening drug and therapeutic targets used for treating Alzheimer's disease
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Application No.: US15570672Application Date: 2015-04-30
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Publication No.: US11236378B2Publication Date: 2022-02-01
- Inventor: Fude Huang , Xiao Zhang , Wenan Wang , Haiyan Liu
- Applicant: Jiangsu Nuo-Beta Pharmaceutical Technology Co., Ltd.
- Applicant Address: CN Jiangsu
- Assignee: Jiangsu Nuo-Beta Pharmaceutical Technology Co., Ltd.
- Current Assignee: Jiangsu Nuo-Beta Pharmaceutical Technology Co., Ltd.
- Current Assignee Address: CN Jiangsu
- Agency: Goodwin Procter LLP
- International Application: PCT/CN2015/078070 WO 20150430
- International Announcement: WO2016/172955 WO 20161103
- Main IPC: A61P25/28
- IPC: A61P25/28 ; C12Q1/02 ; G01N33/68 ; C07K14/47 ; A01K67/033
Abstract:
Disclosed is the use of genetic means or a related inhibitor to inhibit and down-regulate the amount of PI4KIIIα protein, RBO/EFR3/EFR3A/EFR3B membrane proteins, TTC7 protein and membrane protein complexes formed by said proteins, or related enzyme activity to promote Aβ secretion by neuronal cells, reduce Aβ accumulation within neurons, and thereby reduce AD model fruit fly and mouse nerve dysfunction.
Public/Granted literature
- US20190211371A1 Method For Screening Drug And Therapeutic Targets Used For Treating Alzheimer's Disease Public/Granted day:2019-07-11
Information query
