Example seal glands for butterfly valves are disclosed herein. An example butterfly valve disclosed herein includes a valve body and a valve retainer mounted to the valve body, where the valve body and the valve retainer define a circumferential cavity. The example circumferential cavity includes a first surface substantially perpendicular to a longitudinal axis of a flow path of process fluid through the butterfly valve, a second surface substantially perpendicular to the longitudinal axis, where the second surface offset from the first surface, and a third surface extending between the first surface and the second surface. In the example butterfly valve, the first surface, the second surface, and the third surface enable a seal to translate within the cavity in a direction substantially parallel to the first surface.