Embodiments of the present disclosure provide a touch display substrate, a method for manufacturing the same, a driving method thereof, and a display device thereof. The touch display substrate includes a substrate, a plurality of electrode blocks, independent of each other and arranged in an array, disposed on the substrate, and a switching device disposed between the adjacent electrode blocks. The electrode block is configured to receive a common voltage during a display period and receive a touch scan signal during a touch period. The switching device is configured to electrically connect the adjacent electrode blocks during the display period and electrically isolate the adjacent electrode blocks from each other during the touch period.