The present disclosure discloses a driving method and device of a touch display panel. The driving method includes: acquiring image data of an image to be displayed; judging whether the acquired image data is a reloaded picture with a default polarity mode; performing polarity adjustment on the image data when judging that the image data is a reloaded picture with a default polarity mode; and driving the touch display panel to display image according to the image data after polarity adjustment. Wherein the default polarity mode includes: the polarities of image data corresponding to each two adjacent data lines are opposite, while the polarities of image data corresponding to the same data line are the same.