A touch substrate, a touch display panel, a touch display device, and a touch driving method are provided. The touch substrate includes: a base substrate, on which a touch electrode pattern is formed. The touch electrode pattern includes at least one electrode group, and each electrode group includes a driving electrode and a sensing electrode which are arranged in a row along a first direction of the base substrate and insulated from each other. In each electrode group, the driving electrode has a plurality of driving electrode portions coupled to each other, and the sensing electrode has a plurality of sensing electrode blocks. Each driving electrode portion is respectively between two adjacent sensing electrode blocks; and the sensing electrode block has a plurality of sensing electrode regions with different areas.