A method of performing deduplication is provided. The method includes (a) selecting, by applying a deterministic selection criterion, a sub-block of a block of data that contains multiple sub-blocks; (b) performing a lookup, into a deduplication table, of a digest generated by hashing the selected sub-block, the lookup matching an entry indexed by the digest in the deduplication table, the entry identifying a previously processed block; and (c) effecting storage of the block, including pointing to the previously processed block. An apparatus, system, and computer program product for performing a similar method are also provided.