A method of operating a targeting system simulation tool (TSST) includes providing a TSST configured to receive an obstacle/effect parameterization, a simulation parameterization, a sensor parameterization, an aircraft parameterization, and an autonomy parameterization. The method further includes receiving by the TSST, at least one of each of an obstacle/effect parameterization and a simulation parameterization. The method further includes receiving by the TSST, either (1) a sensor parameterization or (2) an aircraft parameterization. The method further includes operating the TSST to apply the provided ones of the obstacle/effect parameterization, simulation parameterization, sensor parameterization, and aircraft parameterization to generate a value, value range, or value limit for the unprovided aircraft parameterization or unprovided sensor parameterization.