Invention Grant
- Patent Title: Community assignments in identity by descent networks and genetic variant origination
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Application No.: US17044223Application Date: 2019-04-04
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Publication No.: US11238957B2Publication Date: 2022-02-01
- Inventor: Jake Kelly Byrnes , Julie M. Granka , Shannon Hateley , Ladan Doroud
- Applicant: ANCESTRY.COM DNA, LLC
- Applicant Address: US UT Lehi
- Assignee: ANCESTRY.COM DNA, LLC
- Current Assignee: ANCESTRY.COM DNA, LLC
- Current Assignee Address: US UT Lehi
- Agency: Fenwick & West LLP
- International Application: PCT/IB2019/052788 WO 20190404
- International Announcement: WO2019/193551 WO 20191010
- Main IPC: G01N33/48
- IPC: G01N33/48 ; G16B20/20 ; G06N20/00 ; G16B30/10 ; G16B40/00 ; G16B20/40

Abstract:
Disclosed are techniques for characterizing variants of interest and predicting assignments of individuals to communities based on obtained genetic information. To characterize a variant, DNA datasets of reference individuals are accessed and used to generate a cluster with additional individuals. Reference individuals carry a variant at a genetic locus and the additional individuals share IBD with reference individuals. Statistics of genealogical data of the cluster are generated. A result summarizing the characterization of the variant is generated based on the statistics. To determine if an individual belongs to a community, a subset of the individual's haplotypes are inputted into a community-specific model. The model is trained using the training samples that each include haplotypes of reference individuals and a label identifying whether the reference individual belongs to the community. Based on the output of the model, it is determined whether the individual is a member of the community.
Public/Granted literature
- US20210057041A1 Community Assignments in Identity by Descent Networks and Genetic Variant Origination Public/Granted day:2021-02-25
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