Systems and methods for using a reconfigurable multi-manager observer system to identify markers are provided. The system allows for easy collaboration among users of the system and with subjects. Systems and methods may comprise receiving subject data, selecting predictor and outcome variable classes based on the data, generating a predictor score based on the data and a predictor rule, generating an outcome score based on the data and an outcome rule, generating a marker score based on the predictor score and a marker rule, generating a marker metric based on the outcome score, the marker score, and a marker relationship, and, optionally, taking an action based on the predictor score, the outcome score, the marker score, or the marker metric.