Echo cancellation in multiple port Full Duplex (FDX) nodes and amplifiers may be provided. First, a plurality of signals may be provided to a cancelation device. Each of the plurality of signals may be configured to provide the cancelation device with a corresponding plurality of configurations. Next, a plurality of effective echo power values respectively corresponding to the plurality of configurations may be received. A one of the plurality of configurations corresponding to a lowest of the plurality of effective echo power values may then be selected. The cancelation device may then be operated at the selected one of the plurality of configurations.