Systems and methods for modernizing workspace and hardware lifecycle management in an enterprise productivity ecosystem are described. In some embodiments, a client Information Handling System (IHS) may include a processor and a memory, the memory having program instructions that, upon execution by the processor, cause the client IHS to: receive, from a workspace orchestration service, one or more files or policies configured to enable the client IHS to instantiate a first workspace based upon a first workspace definition; allow a user to execute a non-vetted application in the first workspace; determine that the first workspace is compromised; and receive, in response to the determination, from the workspace orchestration service, one or more other files or policies configured to enable the client IHS to instantiate a second workspace based upon a second workspace definition, where the second workspace definition allows execution of a vetted application corresponding to the non-vetted application.