A method and apparatus for a transmission mode with user equipment (UE) independent physical downlink shared channel (PDSCH) scrambling for inter-cell and intra-cell PDSCH-to-PDSCH interference cancellation. A method may include configuring (610) a first identifier (e.g. first RNTI) for a first UE. The method may also include performing at least one of indicating (620) (e.g. semi-statically) a second identifier (e.g. PDSCH RNTI own) for the first UE, or indicating (630) (e.g. semi-statically) a third identifier (e.g. PDSCH RNTIJnt) for the first UE. The first identifier (e.g. first RNTI) is for at least one of operation of physical downlink control channel (PDCCH) of the first UE, or operation of PDSCH of the first UE if the second identifier (e.g. PDSCH RNTI own) is not indicated to the first UE; the second identifier (e.g. PDSCH RNTI own) is for at least one of scrambling or descrambling PDSCH of the first UE; and the third identifier (e.g. PDSCH RNTIJnt) is for at least one of scrambling or descrambling a PDSCH of a second (e.g. interfering) UE. The transmission of the second UE may cause interference on the reception of a PDSCH at the first UE.