The use of an active ingredient obtained from Calendula officinalis flowers as a product with topical application on the skin in the prevention or treatment of cutaneous manifestations caused by an imbalance of the epigenome in skin cells. Also, a hydrolyzate of Calendula officinalis flowers including oligosaccharides with a degree of polymerization of between 2 and 10, of fructose and glucose, with the compositions including it, and a cosmetic skin-care process.