A high-lift actuation system for differentially actuating a plurality of high-lift surfaces of an aircraft is disclosed. An exemplary high-lift actuation system includes a centralized drive device for centralized actuation control of an inboard high-lift surface of a first wing and a second wing, respectively, and at least two independent drive devices for individual actuation control of an outboard high-lift surface of the first wing and the second wing, respectively. The centralized drive device may include a central power drive unit (PDU) operably coupled to a common central driveline for driving the inboard high-lift surfaces, and the common central driveline may be separate and spaced apart from a respective driveline of the independent drive devices. The common central driveline may mechanically synchronize movement of the inboard high-lift surfaces, and a controller may electronically coordinate synchronized movement and controlled differential movement of the plurality of high-lift surfaces.