Invention Grant
- Patent Title: Chemical inhibition of the E3 ligase subunit FBXO7 confers neuroprotection and anti-inflammatory activity by stabilizing mitochondria
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Application No.: US16624843Application Date: 2018-06-25
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Publication No.: US11242339B2Publication Date: 2022-02-08
- Inventor: Rama K. Mallampalli , Beibei Chen , Charleen T. Chu , Yuan Liu
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education , The United States Government as represented by the Department of Veterans Affairs
- Applicant Address: US PA Pittsburgh; US DC Washington
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education,The United States Government as represented by the Department of Veterans Affairs
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education,The United States Government as represented by the Department of Veterans Affairs
- Current Assignee Address: US PA Pittsburgh; US DC Washington
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2018/039327 WO 20180625
- International Announcement: WO2019/005685 WO 20190103
- Main IPC: C07D405/12
- IPC: C07D405/12 ; A61P25/28 ; A61P25/16 ; A61K31/517
Abstract:
A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R3-R7 is independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy; R8 is an optionally-substituted heterocycloalkyl; and a is 0 to 3.
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