Invention Grant
- Patent Title: Anti-TGF-beta antibodies and their use
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Application No.: US16931198Application Date: 2020-07-16
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Publication No.: US11242384B2Publication Date: 2022-02-08
- Inventor: Gary Shapiro , Kevin Brower , Patrick Finn , Richard C. Gregory , Rao Koduri , Feng Liu , Natalia Malkova , Parminder Mankoo , Jack R. Pollard , Huawei Qiu , Joachim Theilhaber , Christopher Winter , Marcella Yu
- Applicant: SANOFI
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Agency: Steptoe & Johnson LLP
- Agent Z. Ying Li; Mauricio Alvarez
- Priority: EP17305061 20170120
- Main IPC: C07K16/22
- IPC: C07K16/22 ; A61P35/00 ; C07K16/28 ; C07K16/30 ; C07K16/32 ; A61K39/00
Abstract:
The invention provides an improved pan-TGF-β antibody for treatment of conditions that are mediated by TGF-β, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
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