Invention Grant
- Patent Title: Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target
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Application No.: US16544357Application Date: 2019-08-19
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Publication No.: US11242387B2Publication Date: 2022-02-08
- Inventor: Lieping Chen , Scott E. Strome , Eugene D. Kwon
- Applicant: Mayo Foundation for Medical Education and Research
- Applicant Address: US MN Rochester
- Assignee: Mayo Foundation for Medical Education and Research
- Current Assignee: Mayo Foundation for Medical Education and Research
- Current Assignee Address: US MN Rochester
- Agency: Fish & Richardson P.C.
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07K16/28 ; C12Q1/6886 ; G01N33/50 ; G01N33/569 ; G01N33/574 ; A61K38/20 ; A61K38/21 ; C07K16/30 ; A61K39/00
Abstract:
The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
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