- Patent Title: Bispecific antigen binding molecules comprising anti-FAP clone 212
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Application No.: US16588780Application Date: 2019-09-30
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Publication No.: US11242396B2Publication Date: 2022-02-08
- Inventor: Peter Bruenker , Harald Duerr , Christian Klein , Pablo Umana , Alexander Bujotzek , Joerg Zielonka , Christine Trumpfheller , Moritz Rapp , Marine Le Clech
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Agent Robin A. Weatherhead
- Priority: EP18197866 20181001
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61P35/00 ; A61K39/395 ; C07K1/16 ; C07K16/40 ; A61K39/00
Abstract:
The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP) comprising FAP clone 212 or variants thereof, and (b) at least one antigen binding domain capable of specific binding to CD40, and to methods of producing these molecules and to methods of using the same.
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