Invention Grant
- Patent Title: Monoclonal antigen-binding proteins to intracellular oncogene products
-
Application No.: US15710384Application Date: 2017-09-20
-
Publication No.: US11242405B2Publication Date: 2022-02-08
- Inventor: David A. Scheinberg , Tao Dao , Cheng Liu
- Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER , EUREKA THERAPEUTICS, INC.
- Applicant Address: US NY New York; US CA Emeryville
- Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER,EUREKA THERAPEUTICS, INC.
- Current Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER,EUREKA THERAPEUTICS, INC.
- Current Assignee Address: US NY New York; US CA Emeryville
- Main IPC: C07K16/40
- IPC: C07K16/40 ; C07K16/28 ; A61K47/68 ; A61K39/00

Abstract:
Antigen binding proteins specific for an HLA-A2 restricted Ras peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab′)2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, and bispecific antibodies incorporating the specificity of the antigen binding region for each peptide are also contemplated by the disclosure. Furthermore, immunoconjugates may include antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the disclosure. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function.
Public/Granted literature
- US20210332150A9 MONOCLONAL ANTIGEN-BINDING PROTEINS TO INTRACELLULAR ONCOGENE PRODUCTS Public/Granted day:2021-10-28
Information query