- Patent Title: Compositions and methods for the treatment of hypercholesterolemia
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Application No.: US16483392Application Date: 2018-02-02
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Publication No.: US11242531B2Publication Date: 2022-02-08
- Inventor: Kevin V. Morris , Roslyn Ray
- Applicant: CITY OF HOPE
- Applicant Address: US CA Duarte
- Assignee: CITY OF HOPE
- Current Assignee: CITY OF HOPE
- Current Assignee Address: US CA Duarte
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- International Application: PCT/US2018/016727 WO 20180202
- International Announcement: WO2018/144935 WO 20180809
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/113 ; A61P3/06 ; A61K31/713
Abstract:
Provided herein are, inter alia, compositions and methods for the treatment of hypercholesterolemia. The compositions include double-stranded and single-stranded RNAs capable of repressing IncRNA and concomitantly increasing LDLR activation. The compositions are useful for activating LDLR in liver cells.
Public/Granted literature
- US20200040343A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA Public/Granted day:2020-02-06
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