A wheel comprehensive detecting device, comprises a lower lifting and rotating system, a measuring system I, a measuring system II, a upper pressing system, a translation system, a measuring system III, a measuring system IV. The present disclosure in use is capable of measuring the wheel bolt hole position, the runout of the flange plane, the runouts of the upper and lower rim end faces, the runouts of the upper and lower bead seats, the height of counterbore end face of the bolt hole, the height and offset of the riser end face, etc.