A system and method for aligning a target to a vehicle for calibration of a sensor equipped on the vehicle includes multiple non-contact wheel alignment sensors configured for use in determining the orientation of tire and wheel assemblies of the vehicle. A target adjustment frame includes a target mount moveably mounted on a base frame, and includes multiple actuators configured to selectively move the target mount relative to the base frame, where the base frame is in a known orientation to the non-contact wheel alignment sensors. A computer system selectively actuates the actuators to position a target relative to the vehicle, with the target mount being moveable about a plurality of axes based on the determination of the orientation of the vehicle relative to the target adjustment frame to position the target relative to a sensor of the vehicle whereby the sensor is able to be calibrated using the target.