An intelligent leakage current detection and interruption device for a power cord, including a switch module configured to control electrical connection of first and second power lines between input and output ends; a leakage current detection module, including first and second leakage current detection lines coupled in series, configured to detect a leakage current on the first and second power lines, respectively; a detection monitoring module, coupled in series to the first and second leakage current detection lines and to the first and second power lines, configured to detect an open circuit condition in the first or second leakage current detection line; and a drive module, coupled to the switch module, the leakage current detection module and the detection monitoring module, configured to drive the switch module to cut off power to the output end in response to any detected leakage current or open circuit condition.