Technology for optimizing automated inventory management is described. In an example implementation, a method, implemented using one or more computing devices, may generate unit identifier sets based on affinities between items uniquely identified by the unit identifiers, determine first and second contribution values for each of the unit identifier sets, and calculate a difference between the first and the second contribution values for each of the unit identifier sets. The method may further calculate an incremental carton and expense prevention opportunity (ICEPO) value for the unit identifier sets, calculate an adjusted fulfillment center stocking score using the ICEPO value and the difference between the first and the second contribution values for each of the unit identifier sets, select a subset of the unit identifier sets based on the adjusted fulfillment center stocking score, and output the subset to an inventory replenishment system that manages stocking of items.