The present disclosure is directed toward systems, methods, and non-transitory computer readable media that dynamically modify content distribution campaigns based on triggering conditions and actions. In particular, systems described herein can provide a user interface for display to a publisher device that includes a plurality of selectable options for setting triggering conditions and/or actions. For example, the disclosed systems can utilize a machine learning model to generate suggested triggering conditions and/or actions for one or more content distribution campaigns of a provider. Moreover, the disclosed systems can generate custom rules based on selected triggering conditions and actions and apply the custom rules during execution of digital content campaigns. For instance, the disclosed systems can monitor performance of content campaigns, detect triggering conditions, and dynamically modify digital content campaigns based on actions corresponding to the triggering conditions.