A display panel and an image data compensation method thereof are provided. The display panel includes a first data driving module and a second data driving module. The first data driving module is configured to provide image data signals for a first display area and perform De-Mura compensation. The second data driving module is configured to provide image data signals for a second display area and perform De-Mura compensation. The first data driving module is configured to obtain image data of the second display area after De-Mura compensation, and adjust image data of a first compensation area adjacent to the second display area in the first display area. The second data driving module is configured to obtain image data of the first display area after De-Mura compensation, and adjust image data of a second compensation area adjacent to the first display area in the second display area.