The present disclosure discloses a driving method and driving device of a display panel and a display device. Under the partial display mode, different gamma curves may be called for different display regions, to drive different regions of the same picture. In one embodiment, a first gamma curve with relatively low brightness may be called for a first display region provided with an under screen sensor, that is, the first display region is driven by the first gamma curve with the relatively low brightness. A second gamma curve with relatively high brightness may be called for a second display region in normal display, that is, the second display region is driven by the second gamma curve with the relatively high brightness.