Described herein are multiple designs for an improved analog switch for use in transmitting high voltage signals without using high voltage power supplies for the switch. The analog switches are able to pass and block input signals in the approximate range of −100 V to +100 V. The use of translinear loops and a bootstrap configuration results in a constant on-resistance of the symmetrical switches and matches the conductance of each analog switch to the transconductance of an NMOS transistor, which can be easily stabilized with a constant gm biasing scheme. In certain embodiments, a shunt termination (T-switch) configuration is used for better off-isolation, and each of the symmetrical switches has its own translinear loop and thus flexibility of on-resistance and termination voltage.