Invention Grant
- Patent Title: Engineered scaffolds for vascularized tissue repair
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Application No.: US16124505Application Date: 2018-09-07
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Publication No.: US11246961B2Publication Date: 2022-02-15
- Inventor: Aijun Wang , Kit Lam
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: A61L27/22
- IPC: A61L27/22 ; C07K14/78 ; A61L27/16 ; A61L27/18 ; A61L27/38 ; C07K7/64 ; C08L27/18 ; C08L67/04 ; A61K38/00
Abstract:
The present invention provides scaffolds that include a polymer and a cyclic peptide ligand. The peptide ligand increases the attachment of endothelial cells and/or progenitor cells to the scaffold. The present invention also provides engineered tissues that include the provided scaffolds. The present invention also provides coatings that include a coating polymer and a cyclic peptide ligand. The present invention also provides methods of improving endothelialization and vascularization of endothelial cells and/or progenitor cells for tissue regeneration in a subject and of repairing bone defects in a subject, by implanting a provided scaffold.
Public/Granted literature
- US20190247539A1 ENGINEERED SCAFFOLDS FOR VASCULARIZED TISSUE REPAIR Public/Granted day:2019-08-15
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