An electro-simulation system includes an electro-stimulation device where the supplementary motor area, premotor area and/or subthalamic nucleus are stimulated extra-cranially. The electro-stimulation device includes at least one electrode, said at least one electrode being provided with a stimulation end configured to be directly attached to intrinsic auricular muscles of a human so as to establish a direct contact relation therewith, said stimulation end being operatively coupled with a sensor.