Invention Grant
- Patent Title: Piperazine heteroaryl derivative, preparation method therefor and use of same in medicine
-
Application No.: US16632973Application Date: 2018-07-26
-
Publication No.: US11247998B2Publication Date: 2022-02-15
- Inventor: Xin Li , Wei He , Yang Chen , Feng He , Weikang Tao
- Applicant: JIANGSU HENGRUI MEDICINE CO., LTD. , SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.
- Applicant Address: CN Lianyungang; CN Shanghai
- Assignee: JIANGSU HENGRUI MEDICINE CO., LTD.,SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.
- Current Assignee: JIANGSU HENGRUI MEDICINE CO., LTD.,SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.
- Current Assignee Address: CN Lianyungang; CN Shanghai
- Agency: Morgan, Lewis & Bockius LLP
- Agent Christopher J. Betti; Estella M. Gustilo
- Priority: CN201710621744.9 20170727,CN201711058986.8 20171101
- International Application: PCT/CN2018/097170 WO 20180726
- International Announcement: WO2019/020070 WO 20190131
- Main IPC: C07D241/36
- IPC: C07D241/36 ; C07D487/00 ; A61K31/495 ; C07D487/04 ; A61P31/12 ; A61K31/4985
Abstract:
The present invention relates to a piperazine heteroaryl derivative, a preparation method therefor and the use of same in medicine. In particular, the present invention relates to the piperazine heteroaryl derivative as shown in the general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and the use of same as a capsid protein inhibitor, in particular in the prevention and/or treatment of diseases such as hepatitis B, influenza, herpes, AIDS, etc. The definitions of each group in the general formula (I) are the same as those defined in the description.
Public/Granted literature
- US20200157111A1 PIPERAZINE HETEROARYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE OF SAME IN MEDICINE Public/Granted day:2020-05-21
Information query
