Invention Grant
- Patent Title: Pyrimidine derivative having effect of inhibiting cancer cell growth and pharmaceutical composition containing same
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Application No.: US16766350Application Date: 2018-12-06
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Publication No.: US11248003B2Publication Date: 2022-02-15
- Inventor: Sung-Eun Kim , Sunho Lee , Rengasamy Rajesh , Dae Ho Kang , Hyung Chui Ryu , Jae-Sun Kim , Sangryul Lee , Kyong Cheol Kim , Jin Kyung Rho , Jae Cheol Lee
- Applicant: ONCOBIX CO., LTD.
- Applicant Address: KR Yongin-si
- Assignee: ONCOBIX CO., LTD.
- Current Assignee: ONCOBIX CO., LTD.
- Current Assignee Address: KR Yongin-si
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2017-0167809 20171207,KR10-2018-0154838 20181205
- International Application: PCT/KR2018/015437 WO 20181206
- International Announcement: WO2019/112344 WO 20190613
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D403/14 ; A61K31/506 ; A61P35/00 ; C07D495/04 ; C07D401/12 ; C07D473/16 ; C07D487/04
Abstract:
A novel pyrimidine derivative compound and a salt thereof are disclosed. The pyrimidine derivative compound effectively inhibits the growth of C797S mutant EGFR-expressed and MET-amplified cancer cells, which are the main resistance mechanisms of third generation EGFR anticancer agents, and thus may be effectively used in the treatment of lung cancer.
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