Invention Grant
- Patent Title: Mutant tumor necrosis factor receptor superfamily (TNFsfR) ligands and methods of making and using same
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Application No.: US16717373Application Date: 2019-12-17
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Publication No.: US11248036B2Publication Date: 2022-02-15
- Inventor: Christopher Nelson , Steven Teitelbaum , Daved Fremont , Julia T. Warren
- Applicant: Washington University
- Applicant Address: US MO St. Louis
- Assignee: Washington University
- Current Assignee: Washington University
- Current Assignee Address: US MO St. Louis
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C12N15/12 ; C12N15/63 ; A61K38/00
Abstract:
Methods for constructing efficient inhibitors of target TNF superfamily receptors, single chain target TNF superfamily ligands that inhibit of target TNF superfamily receptors while failing to engage or inhibit non-target TNF superfamily receptors, and methods of their use to treat diseases are provided. Single chain RANKL, TNF, and TRAIL ligands that effectively inhibit their target receptors while failing to inhibit non-target TNF superfamily receptors are also provided.
Information query
