Invention Grant
- Patent Title: Immunoglobulin single variable domain antibody against RSV prefusion F protein
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Application No.: US16566542Application Date: 2019-09-10
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Publication No.: US11248039B2Publication Date: 2022-02-15
- Inventor: Xavier Saelens , Bert Schepens , Iebe Rossey , Barney Graham , Jason McLellan , Morgan Gilman
- Applicant: VIB VZW , UNIVERSITEIT GENT , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , TRUSTEES OF DARTMOUTH COLLEGE
- Applicant Address: BE Ghent; BE Ghent; US MD Bethesda; US NH Hanover
- Assignee: VIB VZW,UNIVERSITEIT GENT,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,TRUSTEES OF DARTMOUTH COLLEGE
- Current Assignee: VIB VZW,UNIVERSITEIT GENT,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,TRUSTEES OF DARTMOUTH COLLEGE
- Current Assignee Address: BE Ghent; BE Ghent; US MD Bethesda; US NH Hanover
- Agency: Lathrop GPM LLP
- Agent James H. Velema, Esq.; Judith L. Stone-Hulslander
- Priority: EP15178653 20150728,EP15191868 20151028
- Main IPC: C07K16/10
- IPC: C07K16/10 ; A61P31/14 ; A61K39/12 ; A61K39/00
Abstract:
The present invention relates to immunoglobulin single variable domains (ISVDs) that are directed against respiratory syncytial virus (RSV). More specifically, it relates to ISVDs that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these ISVDs for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these ISVDs.
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