Invention Grant
- Patent Title: Antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
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Application No.: US16282834Application Date: 2019-02-22
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Publication No.: US11248052B2Publication Date: 2022-02-15
- Inventor: Yang Li , Jennitte LeAnn Stevens , Chadwick Terence King , Ian Nevin Foltz , Gunasekaran Kannan , Junming Yie , Shaw-Fen Sylvia Hu
- Applicant: Amgen, Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen, Inc.
- Current Assignee: Amgen, Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/71 ; C07K16/40 ; A61K39/00
Abstract:
The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing β-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c.
Public/Granted literature
- US20190248906A1 Human Antigen Binding Proteins That Bind to a Complex Comprising Beta-Klotho and an FGF Receptor Public/Granted day:2019-08-15
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