Invention Grant
- Patent Title: Method of RNA in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof
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Application No.: US16012751Application Date: 2016-12-23
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Publication No.: US11248223B2Publication Date: 2022-02-15
- Inventor: Benyamin Yazdan Panah , Aniela Wochner , Tilmann Roos , Andreas Funkner , Martin Kunze
- Applicant: CureVac AG
- Applicant Address: DE Tübingen
- Assignee: CureVac AG
- Current Assignee: CureVac AG
- Current Assignee Address: DE Tübingen
- Agency: Parker Highlander PLLC
- Priority: WOPCT/EP2015/081175 20151223
- International Application: PCT/EP2016/082534 WO 20161223
- International Announcement: WO2017/109161 WO 20170629
- Main IPC: C12N15/10
- IPC: C12N15/10 ; C12P19/34 ; C12Q1/6844
Abstract:
The present invention relates to a buffer system comprising a dicarboxylic acid or tricarboxylic acid or a salt thereof for synthesizing RNA molecules as well as a method of RNA in vitro transcription using this buffer system. The present invention also provides the use of this buffer system in RNA in vitro transcription and in the reduction or prevention of precipitates during RNA in vitro transcription.
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