A control system and method for a frostless, multivariable coupling and heat pump-based hot blast stove are used for grain drying. A first heat exchanger, a second heat exchanger, a main solution pool, corresponding pipelines, and a temperature detector are configured in the control system. A first heat pump unit, a second heat pump unit and a third heat pump unit are formed. A preheating zone, a low temperature zone, a medium temperature zone and a high temperature zone are sequentially formed on an air supply pipeline from a fresh air inlet to a fresh air outlet. A frostless operation procedure is provided. Through the configuration, the control system and method for a frostless, multivariable coupling and heat pump-based hot blast stove can implement heat supply in a gradient heat-circulation preheating mode and a gradient heat-circulation frostless mode.