A computer-implemented method manages I/O queues in a host clustered system. The method includes, receiving, from a first virtual machine (VM), a request to establish a set of I/O queues in a storage system, and the first VM is supported by a first host. The method further includes, mapping a data volume to a target storage system, wherein the data volume is related to the request. The method includes, sending a first connection request from the first host to the target storage system. The method further includes, establishing, in response to the first connection request, a connection between the first host and the target storage system. The method incudes, blocking a second connection request, wherein the second connection request is directed to a second storage system, the second storage system being included in the storage system.