The present disclosure relates to a method of manufacturing a display screen and a special-shaped display screen. The method of manufacturing the display screen includes the following steps: processing the display screen by a material-reduction process to form the display screen with a first mounting groove; and processing the first mounting groove by a material-reduction process to form a second mounting groove. The display screen includes opposite disposed upper and lower surfaces, the first mounting groove and the second mounting groove extend through the upper surface and the lower surface, and a curvature radius of an orthographic projection of the second arcuate transition surface on a plane.