The present invention relates to image contrast enhancement. In order to provide improved and stable contrast enhancement for each acquired image, a device (10) for image contrast enhancement of an X-ray image of a vascular structure is provided. The device (10) comprises an input unit (12) and a processing unit (14). The input unit is configured to provide an acquired X-ray image of a vascular structure with a contrast injection. The contrast injection is performed with a current contrast injection setting having at least one contrast injection parameter. The input unit is further configured to provide a generic vascular structure. The input unit is also configured to provide the current contrast injection setting. The processing unit is configured to determine an assessed contrast parameter for the generic vascular structure based on the current contrast injection setting. The processing unit is further configured to determine an adapted image contrast enhancement for the generic vascular structure based on the assessed contrast parameter. The processing unit is also configured to apply the adapted image contrast enhancement to the acquired X-ray image in order to generate a contrast-enhanced X-ray image.