Invention Grant
- Patent Title: Anti-inflammatory peptides, and uses thereof
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Application No.: US16569159Application Date: 2019-09-12
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Publication No.: US11253456B2Publication Date: 2022-02-22
- Inventor: Nora Khaldi , Cyril Lopez , Alessandro Adelfio
- Applicant: NURITAS LIMITED
- Applicant Address: IE South Dublin
- Assignee: NURITAS LIMITED
- Current Assignee: NURITAS LIMITED
- Current Assignee Address: IE South Dublin
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Ravinderjit Braich
- Priority: EP15177013 20150716,EP15177017 20150716
- Main IPC: A61K8/64
- IPC: A61K8/64 ; A61K9/00 ; C07K14/415 ; A61P29/00 ; A61K9/14 ; A61K38/00

Abstract:
An anti-inflammatory peptide comprises an anti-inflammatory fragment of a protein selected from SEQ ID NOs: 1 to 16, the anti-inflammatory fragment being 7 to 37 amino acids in length and having a charge of between −9 and +3; wherein the c-terminal amino acid is not cysteine (C) or methionine (M), and the n-terminal amino acid is not cysteine (C), histidine (H), proline (P) or threonine (T). The anti-inflammatory fragment does not contain cysteine (C). The anti-inflammatory fragment is from a region of the proteins of SEQ ID NOs: 1 to 16, which region is characterised by being 17 to 109 amino acids in length and having a charge of between −6 and +4, wherein the c-terminal amino acid of the region is not aspartic acid (D), phenylalanine (F), methionine (M) or tryptophan (W), and the n-terminal amino acid of the region is not aspartic acid (D), histidine (H), methionine (M), proline (P) or tryptophan (W). Examples of peptides are provided in SEQ ID NOs: 71 to 221.
Public/Granted literature
- US20200060956A1 PEPTIDES, AND USES THEREOF Public/Granted day:2020-02-27
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