Invention Grant
- Patent Title: Stabilized modified release Vitamin D formulation and method of administering same
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Application No.: US16448838Application Date: 2019-06-21
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Publication No.: US11253528B2Publication Date: 2022-02-22
- Inventor: Jay A. White , Samir P. Tabash , Sammy A. Agudoawu , Joel Z. Melnick
- Applicant: OPKO IRELAND GLOBAL HOLDINGS, LTD.
- Applicant Address: KY Grand Cayman
- Assignee: OPKO IRELAND GLOBAL HOLDINGS, LTD.
- Current Assignee: OPKO IRELAND GLOBAL HOLDINGS, LTD.
- Current Assignee Address: KY Grand Cayman
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: A61K31/593
- IPC: A61K31/593 ; A61K31/592 ; A61K9/20 ; A61K9/28 ; A61K9/48 ; A61K47/38 ; A61K47/44
Abstract:
A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 and a cellulosic compound. The stabilized formulations exhibit a stable dissolution profile following exposure to storage conditions and demonstrate improved pharmacokinetic parameters compared to unstabilized formulations.
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