Invention Grant
- Patent Title: Polymer-based macromolecular prodrugs
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Application No.: US16969790Application Date: 2019-09-17
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Publication No.: US11253603B2Publication Date: 2022-02-22
- Inventor: Michael Chorny , Ivan Alferiev , Garrett M. Brodeur
- Applicant: The Children's Hospital of Philadelphia
- Applicant Address: US PA Philadelphia
- Assignee: The Children's Hospital of Philadelphia
- Current Assignee: The Children's Hospital of Philadelphia
- Current Assignee Address: US PA Philadelphia
- Agency: RatnerPrestia
- International Application: PCT/US2019/051457 WO 20190917
- International Announcement: WO2020/061007 WO 20200326
- Main IPC: A61K47/60
- IPC: A61K47/60 ; A61K31/4745
Abstract:
Provided are macromolecular prodrugs in which camptothecin analogs are covalently bonded to polymers via ester bonds that are labile under physiological conditions. Also provided are methods of treating cancer, especially neuroblastoma with the macromolecular prodrugs.
Public/Granted literature
- US20210000967A1 POLYMER-BASED MACROMOLECULAR PRODRUGS Public/Granted day:2021-01-07
Information query
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