A vehicle-body structure of a vehicle comprises a front side door provided so as to open and close an opening portion for entrance which is formed by a vehicle-body frame member. The front side door comprises a door panel portion and reinforcement portions provided at a peripheral part of the door panel portion such that at least part of the reinforcement portions overlaps with the vehicle-body frame member in a vehicle side view, the reinforcement portions being configured to reinforce the door panel portion such that when a collision load is inputted to the front side door in a vehicle side collision, a connection state of the door panel portion and the vehicle-body frame member is maintained.