Invention Grant
- Patent Title: Chemical compounds
-
Application No.: US16770673Application Date: 2018-12-12
-
Publication No.: US11254671B2Publication Date: 2022-02-22
- Inventor: Gianpaolo Bravi , Heather Hobbs , Graham George Adam Inglis , Simon Nicolle , Simon Peace
- Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
- Applicant Address: GB Middlesex
- Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
- Current Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
- Current Assignee Address: GB Middlesex
- Agent Robert J. Smith
- Priority: GB1720989 20171215
- International Application: PCT/EP2018/084618 WO 20181212
- International Announcement: WO2019/115640 WO 20190620
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D519/00 ; A61P11/00

Abstract:
The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, L and A are as defined in the description and claims, or pharmaceutically acceptable salts thereof having mTOR kinase inhibitor activity. The invention also relates to pharmaceutical compositions including a compound of formula (I) or a pharmaceutically acceptable salt thereof, and to the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an mTOR kinase inhibitor activity is indicated, and in particular the treatment of idiopathic pulmonary fibrosis.
Public/Granted literature
- US20210163472A1 CHEMICAL COMPOUNDS Public/Granted day:2021-06-03
Information query