Invention Grant
- Patent Title: Benzyl-, (pyridin-3-yl)methyl -or (pyridin-4-yl)-methyl-substituted oxadiazolopyridine derivatives as ghrelin O-acyl transferase (GOAT) inhibitors
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Application No.: US16966483Application Date: 2019-01-28
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Publication No.: US11254688B2Publication Date: 2022-02-22
- Inventor: Thomas Trieselmann , Cedrickx Godbout , Christoph Hoenke , Viktor Vintonyak
- Applicant: Boehringer Ingelheim International GmbH
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent David L. Kershner
- Priority: EP18154824 20180202
- International Application: PCT/EP2019/051989 WO 20190128
- International Announcement: WO2019/149657 WO 20190808
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D519/00
Abstract:
The present invention relates to compounds of general formula (I), wherein the groups R1 and R2 are defined as in claim 1, which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.
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