Invention Grant
- Patent Title: Peptide and its derivatives capable of inhibiting replication of hepatitis V virus in human adipose-derived stem cells and hepatocytes
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Application No.: US15566910Application Date: 2015-04-16
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Publication No.: US11254706B2Publication Date: 2022-02-22
- Inventor: Chen-Lung Lin
- Applicant: Inno Bio-Drug Development Limited
- Applicant Address: VG Tortola
- Assignee: Inno Bio-Drug Development Limited
- Current Assignee: Inno Bio-Drug Development Limited
- Current Assignee Address: VG Tortola
- Agency: Fitch, Even, Tabin & Flannery, LLP
- International Application: PCT/CN2015/076744 WO 20150416
- International Announcement: WO2016/165101 WO 20161020
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/10 ; A61K45/06 ; A61P31/14 ; C07K7/08 ; C07K14/81 ; A61K38/08 ; C07K7/06
Abstract:
Hepatitis C virus (HCV) infection is a leading cause for liver cirrhosis and hepatocellular carcinoma worldwide2. Current therapeutic regimens are usually poorly tolerated and only effective in a proportion of infected individuals. We discovered a peptide with sequence of DEAQETAVSSHEQD (SEQ ID NO: 1), a fragment of rabbit α1-antiproteinase F, and its derivatives DEAQETAVSSHEQ (SEQ ID NO: 2) and QETAVSSHEQD (SEQ ID NO: 3), significantly inhibit serum-borne HCV replication in hADSC and human hepatocytes.
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