Invention Grant
- Patent Title: Fab molecules with a rodent hinge region and a non-rodent CH1 region
-
Application No.: US16348941Application Date: 2017-11-13
-
Publication No.: US11254734B2Publication Date: 2022-02-22
- Inventor: Julia Neugebauer , Steffen Runz , Stefanie Urlinger
- Applicant: MorphoSys AG
- Applicant Address: DE Planegg
- Assignee: MorphoSys AG
- Current Assignee: MorphoSys AG
- Current Assignee Address: DE Planegg
- Agency: Licata & Tyrrell P.C.
- Priority: EP16198591 20161114
- International Application: PCT/EP2017/078991 WO 20171113
- International Announcement: WO2018/087349 WO 20180517
- Main IPC: C07K16/18
- IPC: C07K16/18
Abstract:
The disclosure relates to novel Fab molecules comprising a modified heavy chain constant region. The modified constant region prevents the recognition of the Fab molecules by anti-Fab antibodies present in a host's serum. The disclosure further relates to methods of generating such modified Fab molecules for biological, diagnostic, pharmaceutical and other uses.
Information query
